參賽序號：4-7
海報主題
Evaluating the efficacy of a portable air-fed cold atmospheric plasma device for alleviating burn hypertrophic scar and neuropathic pain
系級
醫學系
指導老師及參賽學生
指導老師：薛元毓
參賽學生：林昱成
構想說明
Burn-induced hypertrophic scars are characterized by persistent inflammation, excessive collagen deposition, tissue stiffness, mechanical hypersensitivity, and neuropathic pain. Current treatments face challenges such as discomfort, recurrence, and low adherence rates. Cold atmospheric plasma (CAP) produces bioactive reactive oxygen and nitrogen species at near-room temperature. CAP has been applied in disinfection and acute wound healing.
However, the effects of treatments on established scars during the remodeling process have not been sufficiently investigated. In this study, the effect of a portable air-fed CAP device on alleviating burn-induced hypertrophic scarring and the resulting neuropathic pain was investigated. A burn was induced on the hind paw of female Sprague-Dawley rats, using a 75°C, 100-g metal block for 10 seconds. Rats were randomly assigned to either an untreated control group or received CAP treatment for 4 or 8 minutes, three times a week, for six weeks after wound closure and scar formation. Scar appearance, Shore OO firmness, von Frey paw withdrawal threshold, histology, and serum biochemical parameters were evaluated. Both CAP regimens significantly reduced scar firmness, scar thickness, and the Scar Elevation Index. Histological examination suggested improved tissue and collagen organization. Paw withdrawal thresholds increased significantly in both CAP groups at Week 4. At Week 6, the 8-minute group remained higher than the control, while the 4-minute group showed a similar trend. The serum levels of AST, BUN, and creatinine remained unchanged, whereas ALT levels slightly increased in both CAP-treated groups.
Portable air-fed CAP facilitated the remodeling of established hypertrophic scars and reduced mechanical hypersensitivity, with the 4-minute regimen yielding results comparable to the 8-minute regimen across most measures.
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